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伴有急迫性粪失禁的急迫性尿失禁患者的骶神经调节结果

Sacral neuromodulation outcomes in patients with urge urinary incontinence and concomitant urge fecal incontinence.

作者信息

Kim Dennis H, Faruqui Nuzhat, Ghoniem Gamal M

机构信息

From the Department of Urology, Cleveland Clinic Florida, Weston, FL.

出版信息

Female Pelvic Med Reconstr Surg. 2010 May;16(3):171-8. doi: 10.1097/SPV.0b013e3181d67c24.

Abstract

OBJECTIVES

: To study the efficacy and safety of sacral neuromodulation (SNM) in women with dual urge incontinence (DUI).

METHODS

: Women with simultaneous urge urinary and urge fecal incontinence (FI) were prospectively identified and tested to determine eligibility for SNM. Those who experienced at least 50% improvement in their urinary symptoms were offered a full implant. Changes in FI were not considered. Validated questionnaires were administered at baseline and during follow-up. Preimplant urodynamic data were collected. Adverse events were recorded.

RESULTS

: A total of 11 women had DUI. All had greater than 50% improvement in their urinary symptoms and underwent full implantation. Average age was 76 years. Median follow-up was 14 months. There were statistically significant improvements in validated questionnaire scores. No women were able to achieve complete simultaneous urinary and fecal continence. Six women (54%) were able to achieve at least a 50% improvement simultaneously in both their urinary and fecal symptoms. Two women (18%) only experienced a significant improvement in their urinary symptoms. One (9%) only experienced significant improvement in her FI. Two (18%) experienced no significant improvement in either their urinary or fecal symptoms. The urodynamic findings did not correlate with outcome. Two patients had transient implant pain. One implant was removed due to lack of efficacy at patient's request.

CONCLUSIONS

: SNM is a safe and effective treatment for DUI. In patients with DUI, complete continence rates may be lower than with either type of incontinence alone. DUI may be the end-organ manifestations of a common neurologic pathway-overactive stimulation or underactive inhibition.

摘要

目的

研究骶神经调节(SNM)治疗双重急迫性尿失禁(DUI)女性患者的疗效和安全性。

方法

前瞻性识别并测试同时存在急迫性尿失禁和急迫性粪失禁(FI)的女性患者,以确定其是否适合SNM治疗。尿症状改善至少50%的患者接受完全植入。未考虑FI的变化。在基线和随访期间使用经过验证的问卷。收集植入前的尿动力学数据。记录不良事件。

结果

共有11名女性患有DUI。所有患者的尿症状均有超过50%的改善并接受了完全植入。平均年龄为76岁。中位随访时间为14个月。经过验证的问卷评分有统计学显著改善。没有女性能够同时实现完全的尿便失禁。6名女性(54%)能够同时在尿和粪症状上至少改善50%。2名女性(18%)仅尿症状有显著改善。1名女性(9%)仅粪失禁有显著改善。2名女性(18%)尿和粪症状均无显著改善。尿动力学结果与结局不相关。2例患者有短暂的植入疼痛。1例植入物因患者要求无效而被取出。

结论

SNM是治疗DUI的一种安全有效的方法。在DUI患者中,完全控尿率可能低于单独一种类型的尿失禁。DUI可能是共同神经通路——过度活跃刺激或抑制不足的终末器官表现。

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