Minim Invasive Ther Allied Technol. 2004 Dec;13(5):340-6. doi: 10.1080/13645700410007011.
This article reviews the use of sacral neuromodulation (SNM) for fecal incontinence. Six case series and one crossover study in which sacral neuromodulation had been used for people with fecal incontinence were selected for assessment. Primary outcomes included the number of fecal incontinent episodes per week, ability to defer defecation and quality of life. Following implantation, 41-75% of patients achieved complete fecal continence and 75-94% experienced improvement in incontinent episodes. The ability of patients to be able to defer defecation and fecal incontinence specific quality of life scores had also improved. There were 19 adverse events amongst 149 patients. The small crossover study reported increased episodes of fecal incontinence when the implantable pulse generator (IPG) was switched off. The evidence suggests that SNM achieves a significant improvement in patients with fecal incontinece resistant to conservative treatment. Follow-up indicates that improvements are maintained over the medium term.
本文综述了骶神经调节(SNM)在大便失禁治疗中的应用。选取了六项病例系列研究和一项交叉研究进行评估,这些研究中骶神经调节已用于大便失禁患者。主要结局包括每周大便失禁发作次数、延迟排便的能力和生活质量。植入后,41%至75%的患者实现了完全大便自控,75%至94%的患者失禁发作次数有所改善。患者延迟排便的能力和大便失禁特异性生活质量评分也有所提高。149例患者中出现了19起不良事件。小型交叉研究报告称,当植入式脉冲发生器(IPG)关闭时,大便失禁发作次数增加。证据表明,SNM可使对保守治疗无效的大便失禁患者有显著改善。随访表明,中期改善情况得以维持。