Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 3901 Rainbow Blvd, MSN 3029, Kansas City, KS 66160, USA.
Adv Exp Med Biol. 2012;740:235-54. doi: 10.1007/978-94-007-2888-2_10.
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate diverse functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times each isoform, contributes to unique cellular functions. This chapter provides a review of the current literature. In addition, references have been provided for more in depth information regarding areas that are discussed. Ultimately, understanding the roles of the individual PLC enzymes, and their distinct cellular functions, will lead to a better understanding of the development of diseases and the maintenance of homeostasis.
磷酸脂酶 C（PLC）家族成员构成了一个多样化的酶家族。已经克隆了十三个不同的家族成员。这些家族成员具有独特的结构，介导多样化的功能。虽然 PLC 家族成员似乎都通过磷酸脂裂解的产物来传递信号，但显然每个家族成员，有时甚至每个同工酶，都有助于独特的细胞功能。本章综述了当前的文献。此外，还提供了有关所讨论领域的更深入信息的参考文献。最终，了解单个 PLC 酶的作用及其独特的细胞功能将有助于更好地理解疾病的发展和内环境的维持。
