心肌肌浆网中的基础钙释放事件。
Elementary calcium release events from the sarcoplasmic reticulum in the heart.
机构信息
Center for Biomedical Engineering and Technology, Department of Physiology, University of Maryland School of Medicine, University of Maryland, 725 W. Lombard Street, Baltimore, MD 21201, USA.
出版信息
Adv Exp Med Biol. 2012;740:499-509. doi: 10.1007/978-94-007-2888-2_21.
Abstract
Ca(2+) release events underlie global Ca(2+) signaling yet they are regulated by local, subcellular signaling features. Here we review the latest developments of different elementary Ca(2+) release features that include Ca(2+) sparks, Ca(2+) blinks (the corresponding depletion of Ca(2+) in the sarcoplasmic reticulum (SR) during a spark) and the recently identified small Ca(2+) release events called quarky SR Ca(2+) release (QCR). QCR events arise from the opening of only a few type 2 ryanodine receptors (RyR2s) - possibly only one. Recent reports suggest that QCR events can be commingled with Ca(2+) sparks and may thus explain some variations observed in Ca(2+) sparks. The Ca(2+) spark termination mechanism and the number of RyR2 channels activated during a Ca(2+) spark will be discussed with respect to both Ca(2+) sparks and QCR events.
摘要
钙释放事件是细胞内钙信号转导的基础，但它们受到局部亚细胞信号特征的调节。本文综述了不同基本钙释放特征的最新研究进展，包括钙火花、钙闪烁（在钙火花期间肌浆网（SR）中钙的相应耗竭）以及最近发现的称为 quarky SR Ca2+释放（QCR）的小钙释放事件。QCR 事件仅由少数几种类型 2 ryanodine 受体（RyR2）开放引起 - 可能只有一个。最近的报告表明，QCR 事件可以与钙火花混合，因此可以解释在钙火花中观察到的一些变化。将讨论钙火花终止机制和钙火花期间激活的 RyR2 通道数量，以及钙火花和 QCR 事件。
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