The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Queensland 4102, Australia.
Mater Research Institute, The University of Queensland, Brisbane, Queensland 4102, Australia.
Nat Rev Cancer. 2017 Jun;17(6):367-380. doi: 10.1038/nrc.2017.18. Epub 2017 Apr 7.
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific outcomes. Cellular machinery important in tumour progression is often driven or influenced by changes in calcium ions; in some cases this regulation occurs within spatially defined regions. Over the past decade there has been a deeper understanding of how calcium signalling is remodelled in some cancers and the consequences of calcium signalling on key events such as proliferation, invasion and sensitivity to cell death. Specific calcium signalling pathways have also now been identified as playing important roles in the establishment and maintenance of multidrug resistance and the tumour microenvironment.
钙信号是细胞实现特定结果的强大而多方面的工具。在肿瘤进展中起重要作用的细胞机制通常受到钙离子变化的驱动或影响；在某些情况下，这种调节发生在空间限定的区域内。在过去的十年中，人们对某些癌症中钙信号如何重塑以及钙信号对增殖、侵袭和对细胞死亡的敏感性等关键事件的后果有了更深入的了解。特定的钙信号通路也已被确定在多药耐药性的建立和维持以及肿瘤微环境中发挥重要作用。
