Tewari Shivendra, Majumdar Kaushik
Systems Science and Informatics Unit, Indian Statistical Institute, 8th Mile, Mysore Road, Bangalore 560059, India.
J Comput Neurosci. 2012 Oct;33(2):341-70. doi: 10.1007/s10827-012-0389-5. Epub 2012 Mar 28.
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP). Recently, Perea and Araque (Science 317:1083-1086, 2007) demonstrated a role of astrocytes in induction of LTP at single hippocampal synapses. They suggested a purely pre-synaptic basis for induction of this N-methyl-D-Aspartate (NMDA) Receptor-independent LTP. Also, the mechanisms underlying this pre-synaptic induction were not investigated. Here, in this article, we propose a mathematical model for astrocyte modulated LTP which successfully imitates the experimental findings of Perea and Araque (Science 317:1083-1086, 2007). Our study suggests the role of retrograde messengers, possibly Nitric Oxide (NO), for this pre-synaptically modulated LTP.
许多当代研究表明，星形胶质细胞在调节短期和长期突触可塑性方面发挥着重要作用。很少有实验模型能够阐明星形胶质细胞在长时程增强（LTP）中的作用。最近，佩雷亚和阿拉克（《科学》317:1083 - 1086，2007）证明了星形胶质细胞在单个海马突触LTP诱导中的作用。他们提出了这种不依赖N - 甲基 - D - 天冬氨酸（NMDA）受体的LTP诱导的纯突触前基础。此外，这种突触前诱导的潜在机制并未得到研究。在此，在本文中，我们提出了一个用于星形胶质细胞调节LTP的数学模型，该模型成功地模仿了佩雷亚和阿拉克（《科学》317:1083 - 1086，2007）的实验结果。我们的研究表明逆行信使，可能是一氧化氮（NO），在这种突触前调节的LTP中发挥作用。
