Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Leipzig AöR, 04103, Leipzig, Germany.
Amino Acids. 2012 Jul;43(1):135-42. doi: 10.1007/s00726-012-1271-5. Epub 2012 Mar 28.
The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination. In the present perspective, a possible use of carnosine as an anti-neoplastic therapeutic, especially for the treatment of malignant brain tumours such as glioblastoma is discussed. Possible mechanisms by which carnosine may perform its anti-tumourigenic effects are outlined and its expected bioavailability and possible negative and positive side effects are considered. Finally, alternative strategies are examined such as treatment with other dipeptides or β-alanine.
肌肽在医学中的应用已经讨论了好几年，但许多声称的治疗效果并没有经过严格的实验检验。在本观点中，讨论了肌肽作为一种抗肿瘤治疗药物的可能用途，特别是用于治疗恶性脑肿瘤，如神经胶质瘤。概述了肌肽可能发挥其抗肿瘤作用的可能机制，并考虑了其预期的生物利用度以及可能的负面和正面副作用。最后，还研究了其他二肽或β-丙氨酸的治疗等替代策略。
