Marin Davide, Marchesan Silvia
Chemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, Italy.
Nanomaterials (Basel). 2022 Jun 22;12(13):2147. doi: 10.3390/nano12132147.
Proteins are functional building blocks of living organisms that exert a wide variety of functions, but their synthesis and industrial production can be cumbersome and expensive. By contrast, short peptides are very convenient to prepare at a low cost on a large scale, and their self-assembly into nanostructures and gels is a popular avenue for protein biomimicry. In this Review, we will analyze the last 5-year progress on the incorporation of bioactive motifs into self-assembling peptides to mimic functional proteins of the extracellular matrix (ECM) and guide cell fate inside hydrogel scaffolds.
蛋白质是生物有机体的功能性组成部分，发挥着各种各样的功能，但其合成和工业生产可能既繁琐又昂贵。相比之下，短肽很容易以低成本大规模制备，并且它们自组装成纳米结构和凝胶是模拟蛋白质仿生的一条热门途径。在本综述中，我们将分析过去五年在将生物活性基序掺入自组装肽中以模拟细胞外基质（ECM）的功能蛋白并引导水凝胶支架内细胞命运方面取得的进展。
