Zdralević Maša, Guaragnella Nicoletta, Antonacci Lucia, Marra Ersilia, Giannattasio Sergio
CNR-Istituto di Biomembrane e Bioenergetica, Via Amendola 165/A, 70126 Bari, Italy.
ScientificWorldJournal. 2012;2012:912147. doi: 10.1100/2012/912147. Epub 2012 Feb 2.
Cell homeostasis results from the balance between cell capability to adapt or succumb to environmental stress. Mitochondria, in addition to supplying cellular energy, are involved in a range of processes deciding about cellular life or death. The crucial role of mitochondria in cell death is well recognized. Mitochondrial dysfunction has been associated with the death process and the onset of numerous diseases. Yet, mitochondrial involvement in cellular adaptation to stress is still largely unexplored. Strong interest exists in pharmacological manipulation of mitochondrial metabolism and signaling. The yeast Saccharomyces cerevisiae has proven a valuable model organism in which several intracellular processes have been characterized in great detail, including the retrograde response to mitochondrial dysfunction and, more recently, programmed cell death. In this paper we review experimental evidences of mitochondrial involvement in cytoprotection and propose yeast as a model system to investigate the role of mitochondria in the cross-talk between prosurvival and prodeath pathways.
细胞稳态源于细胞适应或屈服于环境压力的能力之间的平衡。线粒体除了提供细胞能量外，还参与一系列决定细胞生死的过程。线粒体在细胞死亡中的关键作用已得到充分认识。线粒体功能障碍与死亡过程及多种疾病的发生有关。然而，线粒体在细胞适应压力方面的作用仍 largely unexplored。人们对线粒体代谢和信号传导的药物操纵有着浓厚的兴趣。酿酒酵母已被证明是一种有价值的模式生物，其中几个细胞内过程已被详细表征，包括对线粒体功能障碍的逆行反应，以及最近的程序性细胞死亡。在本文中，我们综述了线粒体参与细胞保护的实验证据，并提出酵母作为一个模型系统来研究线粒体在生存和死亡途径之间的相互作用中的作用。
