Mariappan Meenalakshmi M
Division of Nephrology, Department of Medicine, MC7882, South Texas Veterans Healthcare System, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Exp Diabetes Res. 2012;2012:749812. doi: 10.1155/2012/749812. Epub 2012 Feb 19.
Renal hypertrophy and accumulation of extracellular matrix proteins are among cardinal manifestations of diabetic nephropathy. TGF beta system has been implicated in the pathogenesis of these manifestations. Among signaling pathways activated in the kidney in diabetes, mTOR- (mammalian target of rapamycin-)regulated pathways are pivotal in orchestrating high glucose-induced production of ECM proteins leading to functional and structural changes in the kidney culminating in adverse outcomes. Understanding signaling pathways that influence individual matrix protein expression could lead to the development of new interventional strategies. This paper will highlight some of the diverse components of the signaling network stimulated by hyperglycemia with an emphasis on extracellular matrix protein metabolism in the kidney in diabetes.
肾肥大和细胞外基质蛋白的积聚是糖尿病肾病的主要表现。转化生长因子β系统与这些表现的发病机制有关。在糖尿病肾脏中激活的信号通路中，雷帕霉素哺乳动物靶标（mTOR）调节的通路在协调高糖诱导的细胞外基质蛋白产生方面起着关键作用，导致肾脏的功能和结构变化，最终导致不良后果。了解影响单个基质蛋白表达的信号通路可能会促成新的干预策略的开发。本文将重点介绍高血糖刺激的信号网络的一些不同组成部分，重点是糖尿病肾脏中的细胞外基质蛋白代谢。
