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有机磷中毒患者的临床流行病学特征

Clinico-epidemiological characteristics of patients presenting with organophosphorus poisoning.

作者信息

Banerjee Indranil, Tripathi Sk, Roy A Sinha

机构信息

Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.

出版信息

N Am J Med Sci. 2012 Mar;4(3):147-50. doi: 10.4103/1947-2714.93884.

Abstract

BACKGROUND

Organophosphorus (OP) poisoning is a major health problem all over the world, particularly in the developing countries.

AIM

The present study aims to explore the clinical and epidemiological features found in patients presenting with OP poisoning.

MATERIALS AND METHODS

A 1-year cross-sectional study was conducted on patients presenting with clinical features of OP poisoning in a tertiary care medical college.

RESULTS

A total of 968 patients presented during the study period. Poisoning with suicidal intent (82.02%) was more common than the accidental one (17.98%). Majority of the patients were housewives (42%) followed by farmers, shopkeepers, laborers, students. Methyl parathion was the most common poison consumed by the patients (35.74%) followed by diazinon, chlorpyriphos, dimicron. Nausea and vomiting (85.02%) was the most common symptom while miosis was the most common sign observed in 91.94% patients. A total of 56 patients of OP poisoning died (5.78%) with respiratory failure being the primary cause of death followed by CNS depression, cardiac arrest, and septicaemia.

CONCLUSION

The present study showed that majority of the patients were of young age with females outnumbering males. Poisoning with suicidal intent was more common than accidental. Nausea and vomiting was the most common symptom reported by the patients while miosis was the most common sign observed by the treating physicians of the research team.

摘要

背景

有机磷中毒是全球主要的健康问题,在发展中国家尤为突出。

目的

本研究旨在探讨有机磷中毒患者的临床和流行病学特征。

材料与方法

在一所三级医疗学院对具有有机磷中毒临床特征的患者进行了为期1年的横断面研究。

结果

研究期间共有968例患者就诊。自杀性中毒(82.02%)比意外中毒(17.98%)更为常见。大多数患者为家庭主妇(42%),其次是农民、店主、工人、学生。甲基对硫磷是患者最常摄入的毒物(35.74%),其次是二嗪农、毒死蜱、敌敌畏。恶心和呕吐(85.02%)是最常见的症状,而瞳孔缩小是91.94%患者中最常见的体征。共有56例有机磷中毒患者死亡(5.78%),呼吸衰竭是主要死因,其次是中枢神经系统抑制、心脏骤停和败血症。

结论

本研究表明,大多数患者为年轻人,女性多于男性。自杀性中毒比意外中毒更为常见。恶心和呕吐是患者报告的最常见症状,而瞳孔缩小是研究团队治疗医生观察到的最常见体征。

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