Department of Pharmacology, St Thomas's Hospital Medical School, London.
Br J Clin Pharmacol. 1974 Feb;1(1):37-40. doi: 10.1111/j.1365-2125.1974.tb00203.x.
1 Mydriatic and cycloplegic effects of tropicamide in the normal and in the guanethidine-treated human eye have been recorded following prolonged exposure of the eye to drug solutions. 2 Marked effects and satisfactory dose-response relationships were observed at drug concentrations within the range 1.25-40 μg/ml, by comparison with concentrations of 5-10 mg/ml usually applied as eye-drops. 3 The findings are discussed in relation to drug concentrations which produce cholinergic antagonism in vitro.
本文记录了将药物溶液长时间暴露于眼睛后，正常人和胍乙啶处理过的人眼中托品酰胺的散瞳和睫状肌麻痹作用。
与通常作为眼药水使用的 5-10mg/ml 浓度相比，在 1.25-40μg/ml 的药物浓度范围内观察到明显的效果和令人满意的剂量反应关系。
研究结果与体外产生胆碱能拮抗作用的药物浓度进行了讨论。
