在评估β-肾上腺素能受体阻断药物时异丙肾上腺素和运动诱发的心动过速；托拉洛尔、普拉洛尔和普萘洛尔之间的比较
Isoprenaline- and exercise- induced tachycardia in the assessment of beta-adrenoceptor blocking drugs; a comparison between tolamolol, practolol and propranolol.
作者信息
Adam K R, Pullman L G, Scholfield P C
出版信息
Br J Pharmacol. 1973 Nov;49(3):560-3. doi: 10.1111/j.1476-5381.1973.tb17268.x.
The effects of tolamolol, propranolol and practolol on both isoprenaline- and exercise-induced tachycardia have been studied in conscious dogs. Tolamolol was approximately equipotent to propranolol and 50 times more potent than practolol in antagonizing exercise-induced tachycardias, but was approximately 12 times less potent than propranolol and 8 times more potent than practolol in blocking isoprenaline-induced tachycardia. It is suggested that antagonism of the tachycardia induced by exercise affords a more meaningful assessment of the possible therapeutic potential of beta-adrenoceptor blocking drugs than does that induced by isoprenaline.
已在清醒犬中研究了托拉洛尔、普萘洛尔和普拉洛尔对异丙肾上腺素和运动诱发的心动过速的影响。在对抗运动诱发的心动过速方面，托拉洛尔的效力约与普萘洛尔相当，比普拉洛尔强50倍；但在阻断异丙肾上腺素诱发的心动过速方面，托拉洛尔的效力比普萘洛尔约低12倍，比普拉洛尔强8倍。有人提出，与异丙肾上腺素诱发的心动过速相比，对抗运动诱发的心动过速能更有意义地评估β肾上腺素受体阻断药的潜在治疗潜力。
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