锂治疗强烈抑制人红细胞中的胆碱转运。
Lithium treatment strongly inhibits choline transport in human erythrocytes.
机构信息
Department of Pharmacology, University of Cambridge Medical School, Hills Road, Cambridge.
出版信息
Br J Clin Pharmacol. 1974 Oct;1(5):365-70. doi: 10.1111/j.1365-2125.1974.tb00270.x.
1 The influx of [(14)C]-choline and the efflux of (22)Na in human erythrocytes were measured in vitro using blood from patients treated with lithium, patients not on lithium and healthy individuals. 2 The administration of lithium to patients significantly reduces the transport of choline; during the first 6 weeks of treatment the influx of choline is about half the normal rate, later it falls to around 10%. 3 This inhibition of choline transport is not dependent on the presence of lithium in the incubation medium. 4 The active and passive efflux of sodium are apparently not affected by lithium treatment.
采用锂治疗的患者、未接受锂治疗的患者和健康个体的血液，在体外测量了 [(14)C]-胆碱的内流和 (22)Na 的外流。
锂的给药显著降低了胆碱的转运；在治疗的最初 6 周，胆碱的内流约为正常速率的一半，之后降至约 10%。
这种对胆碱转运的抑制不依赖于孵育介质中锂的存在。
钠的主动和被动外流显然不受锂处理的影响。
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