普萘洛尔治疗轻度高血压的对照试验。
A controlled trial of practolol in mild hypertension.
机构信息
The Department of Clinical Pharmacology and Therapeutics, The London Hospital Medical College, Turner Street, London.
出版信息
Br J Clin Pharmacol. 1974 Oct;1(5):375-8. doi: 10.1111/j.1365-2125.1974.tb00272.x.
1 Fifteen patients with diastolic blood pressures between 90 and 120 mmHg were admitted to a trial comparing placebo with practolol at doses up to 500 mg 12 hourly. 2 The trial was a double blind cross over study. Treatments were allocated at random and each treatment block lasted 12 weeks. 3 Ten patients completed the trial, and none of those who withdrew experienced serious unwanted effects. 4 Practolol caused significant falls in standing systolic and diastolic pressures and the supine diastolic pressure.
15 例舒张压在 90 至 120mmHg 之间的患者被收入一项试验，该试验比较安慰剂与普萘洛尔（剂量高达 500mg，每日 12 次）的疗效。
该试验为双盲交叉研究。治疗方法随机分配，每个治疗阶段持续 12 周。
10 例患者完成了试验，无退出者发生严重不良反应。
普萘洛尔显著降低了站立时的收缩压和舒张压以及仰卧时的舒张压。
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