血浆氢化可的松浓度升高对人体中扑热息痛代谢的影响。
The influence of elevated plasma hydrocortisone concentrations on antipyrine metabolism in man.
机构信息
Poisons Unit, New Cross Hospital, Avonley Road, London.
出版信息
Br J Clin Pharmacol. 1974 Oct;1(5):409-12. doi: 10.1111/j.1365-2125.1974.tb00278.x.
Abstract
1 The plasma half-life of antipyrine was estimated overnight in four healthy volunteers on two separate occasions, one during i.v. infusion of hydrocortisone (3 mg/h) and the second during an infusion of normal saline. 2 The plasma fluorogenic corticosteroid concentration averaged 12.5 μg/100 ml during saline infusion, increasing to 20.1 μg/100 ml during hydrocortisone infusion. 3 The mean antipyrine half-life increased from 9.7 h during saline infusion to 12.6 h during hydrocortisone infusion. 4 No consistent change was found in the apparent volume of distribution or urinary excretion of antipyrine, or of the urinary excretion of D-glucaric acid. 5 The stimulation by hydrocortisone of antipyrine metabolism demonstrated by other workers has not been found.
摘要
四名健康志愿者在两种不同情况下进行了安替比林的血浆半衰期 overnight 估计，一次是在静脉输注氢化可的松（3mg/h）期间，另一次是在输注生理盐水期间。
生理盐水输注期间，血浆荧光皮质激素浓度平均为 12.5μg/100ml，在氢化可的松输注期间增加至 20.1μg/100ml。
安替比林的平均半衰期从生理盐水输注时的 9.7 小时增加到氢化可的松输注时的 12.6 小时。
未发现安替比林的表观分布容积或尿排泄量或 D-葡糖醛酸的尿排泄量有一致的变化。
其他研究人员所证明的氢化可的松对安替比林代谢的刺激作用并未发现。
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