clusterProfiler：一个用于比较基因簇间生物学主题的 R 包。
clusterProfiler: an R package for comparing biological themes among gene clusters.
机构信息
Institute of Life and Health Engineering, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Jinan University, Guangzhou, People's Republic of China.
出版信息
OMICS. 2012 May;16(5):284-7. doi: 10.1089/omi.2011.0118. Epub 2012 Mar 28.
Abstract
Increasing quantitative data generated from transcriptomics and proteomics require integrative strategies for analysis. Here, we present an R package, clusterProfiler that automates the process of biological-term classification and the enrichment analysis of gene clusters. The analysis module and visualization module were combined into a reusable workflow. Currently, clusterProfiler supports three species, including humans, mice, and yeast. Methods provided in this package can be easily extended to other species and ontologies. The clusterProfiler package is released under Artistic-2.0 License within Bioconductor project. The source code and vignette are freely available at http://bioconductor.org/packages/release/bioc/html/clusterProfiler.html.
摘要
从转录组学和蛋白质组学中产生的定量数据不断增加，这就需要综合的分析策略。在这里，我们介绍了一个 R 包 clusterProfiler，它可以自动完成生物术语分类和基因簇的富集分析。分析模块和可视化模块被组合成一个可重复使用的工作流程。目前，clusterProfiler 支持三种物种，包括人类、小鼠和酵母。此包中提供的方法可以轻松扩展到其他物种和本体。clusterProfiler 包在 Bioconductor 项目下以 Artistic-2.0 许可证发布。源代码和示例可在 http://bioconductor.org/packages/release/bioc/html/clusterProfiler.html 免费获得。
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