一锅法无金属 C-H 键活化合成 4-取代异喹啉鎓两性离子盐。
One-pot synthesis of 4-substituted isoquinolinium zwitterionic salts by metal-free C-H bond activation.
机构信息
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
出版信息
Chem Commun (Camb). 2012 May 11;48(37):4492-4. doi: 10.1039/c2cc30708a. Epub 2012 Mar 29.
PMID:22456497
Abstract
The unprecedented isoquinolinium zwitterionic salts with an unusual C-4 substitution pattern were efficiently prepared via the multicomponent reaction of in situ formed N-benzylisoquinolinium bromide with aromatic aldehydes and cyclic 1,3-dicarbonyl compounds.
摘要
通过原位形成的 N-苄基异喹啉溴化物与芳香醛和环状 1,3-二羰基化合物的多组分反应，高效制备了具有不寻常 C-4 取代模式的前所未有的异喹啉鎓两性离子盐。
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