College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Beilstein J Org Chem. 2013 May 13;9:918-24. doi: 10.3762/bjoc.9.105. Print 2013.
A series of functionalized spiro[indoline-3,2'-oxiran]-2-ones was efficiently synthesized by Darzens reaction of phenacyl bromides with isatins both with N-alkyl groups and without N-substituent in the presence of potassium carbonate as a base catalyst. When two equivalents phenacyl bromides were used in the reaction, the N-substitution reaction of isatin also finished with the formation of spiro-oxirane-oxindoles.
通过在碳酸钾作为碱催化剂的存在下，用溴苯乙酮与具有 N-烷基和无 N-取代基的靛红进行 Darzens 反应，高效合成了一系列官能化的螺[吲哚啉-3,2'-恶嗪]-2-酮。当反应中使用两当量的溴苯乙酮时，靛红的 N-取代反应也完成，并形成了螺-氧杂环戊烷-氧吲哚。
