Department of Pediatric Hemato-Oncology, Functional Genomics and Childhood Leukemia Research, Cancer Research Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
Leukemia. 2012 Sep;26(9):2011-8. doi: 10.1038/leu.2012.90. Epub 2012 Mar 29.
MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa-miR-125a). Here we review a recent research on the role of miR-125 in normal and malignant hematopoietic cells. Its high expression in hematopoietic stem cells (HSCs) enhances self-renewal and survival. Its expression in specific subtypes of myeloid and lymphoid leukemias provides resistance to apoptosis and blocks further differentiation. A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models. Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation.
miR-125 是一种高度保守的 microRNA，存在于从线虫到人类的许多不同物种中。在人类中，有三个同源物（hsa-miR-125b-1、hsa-miR-125b-2 和 hsa-miR-125a）。在这里，我们综述了 miR-125 在正常和恶性造血细胞中的作用的最新研究。它在造血干细胞（HSCs）中的高表达增强了自我更新和存活。它在特定类型的髓性和淋巴性白血病中的表达提供了对细胞凋亡的抗性，并阻止了进一步的分化。最近，通过几个小鼠模型证明了 miR-125b 在造血系统中的直接致癌作用。miR-125b 的靶标包括调节细胞凋亡、先天免疫、炎症和造血分化的关键蛋白。
