Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.
Eur J Prev Cardiol. 2013 Aug;20(4):671-7. doi: 10.1177/2047487312444367. Epub 2012 Mar 28.
To evaluate the effects of weight loss on heart rate (HR) and heart rate variability (HRV) parameters in overweight postmenopausal women.
Forty-nine overweight postmenopausal women with an average body mass index of 28.8 ± 1.9 kg/m(2) underwent a 12-week dietary weight-loss programme. Accepted variables for characterization of HRV were analysed before and after the weight loss by 24-h ambulatory ECG monitoring; mean and standard deviation for the time between normal-to-normal complexes (MeanNN and SDNN, respectively), and the mean of standard deviations of normal-to-normal intervals for each 5-min period (SDNNindex). Baseline body fat mass (FM%) and changes in body composition was determined by dual X-ray absorptiometry. Before and after the weight-loss period, total abdominal fat, intra-abdominal fat (IAAT), and subcutaneous abdominal fat (SCAT) were measured by single-slice MRI at L3.
The weight loss of 3.9 ± 2.0 kg was accompanied by an improvement of HRV. SDNN increased by 9.2% (p = 0.003) and SDNNindex increased by 11.4% (p = 0.0003). MeanNN increased by 2.4%, reflecting a decrease in mean heart rate from 74.1 to 72.3 beats/min (p = 0.033). Systolic blood pressure (SBP) decreased by 2.7%, total cholesterol by 5.1% and high-sensitivity C-reactive protein (hsCRP) by 15.8% (p = 0.002). Improvements in SDNN and cholesterol were correlated with weight loss (r = -0.329, p = 0.024 and r = 0.327, p = 0.020, respectively) but changes in HR, SBP, and hsCRP were not. IAAT and the IAAT/SCAT-ratio were found to be negatively associated with HRV parameters but changes in body composition were not associated with changes in HRV.
The observed improvement of HRV seems to be facilitated by weight loss. IAAT and the IAAT/SCAT ratio were found to be associated with low HRV.
评估超重绝经后女性体重减轻对心率（HR）和心率变异性（HRV）参数的影响。
49 名超重绝经后女性平均 BMI 为 28.8±1.9kg/m²，接受为期 12 周的饮食减肥计划。通过 24 小时动态心电图监测，分析减肥前后接受的 HRV 特征变量；正常-正常复合体之间的时间平均值和标准差（MeanNN 和 SDNN 分别），以及每个 5 分钟时间段正常-正常间隔的标准差平均值（SDNNindex）。通过双 X 射线吸收法测定基线体脂肪量（FM%）和身体成分变化。在减肥前后，通过 L3 处的单次磁共振成像测量总腹部脂肪、腹内脂肪（IAAT）和腹部皮下脂肪（SCAT）。
体重减轻 3.9±2.0kg 伴随着 HRV 的改善。SDNN 增加了 9.2%（p=0.003），SDNNindex 增加了 11.4%（p=0.0003）。MeanNN 增加了 2.4%，反映出平均心率从 74.1 次/分降至 72.3 次/分（p=0.033）。收缩压（SBP）降低 2.7%，总胆固醇降低 5.1%，高敏 C 反应蛋白（hsCRP）降低 15.8%（p=0.002）。SDNN 和胆固醇的改善与体重减轻相关（r=-0.329，p=0.024 和 r=0.327，p=0.020），但 HR、SBP 和 hsCRP 的变化与体重减轻无关。IAAT 和 IAAT/SCAT 比值与 HRV 参数呈负相关，但身体成分的变化与 HRV 的变化无关。
观察到的 HRV 改善似乎是由体重减轻促进的。IAAT 和 IAAT/SCAT 比值与低 HRV 相关。
