Zimmermann Paul, Herz Daniel, Karl Sebastian, Weiß Johannes W, Lackner Helmut K, Erlmann Maximilian P, Sourij Harald, Schierbauer Janis, Haupt Sandra, Aberer Felix, Wachsmuth Nadine B, Moser Othmar
Division of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany.
Interdisciplinary Center of Sportsmedicine Bamberg, Klinikum Bamberg, 96049 Bamberg, Germany.
Biology (Basel). 2023 Feb 26;12(3):372. doi: 10.3390/biology12030372.
The impact of a fasting intervention on electrocardiographic (ECG) time intervals and heart rate variability (HRV) is a focus that is scarcely analyzed. The main focus of these secondary outcome data was to describe the impact of a different fasting intervention on ECG and HRV analyses. Twenty-seven healthy individuals participated in this study (11 females, aged 26.3 ± 3.8 years, BMI 24.7 ± 3.4 kg/m), including a pre-intervention controlled run-in period. Participants were randomized to one of the three fasting cohorts: (I) alternate day fasting (ADF, = 8), (II) 16/8 fasting (16/8 h of fasting/feasting, = 11) and (III) 20/4 fasting (20/4 h of fasting/feasting, = 8). An analysis of baseline ECG parameters and HRV parameters following different fasting interventions demonstrated the safety of these interventions without impacting on heart rate variability parameters during Schellong-1 testing, and revealed comparable preserved autonomic cardiac modulation (ACM) independently of the fasting intervention. In conclusion, different short-term fasting interventions demonstrated no safety ECG-based concerns and showed comparable ACM based on ECG and HRV assessments. Finally, our research topic might strengthen the scientific knowledge of intermittent fasting strategies and indicate potential clinically preventive approaches with respect to occurring metabolic disease and obesity in healthy young subjects.
禁食干预对心电图（ECG）时间间隔和心率变异性（HRV）的影响是一个鲜有分析的焦点。这些次要结局数据的主要重点是描述不同禁食干预对心电图和心率变异性分析的影响。27名健康个体参与了本研究（11名女性，年龄26.3±3.8岁，体重指数24.7±3.4kg/m²），包括干预前的对照导入期。参与者被随机分配到三个禁食组之一：（I）隔日禁食（ADF，n = 8），（II）16/8禁食（禁食/进食16/8小时，n = 11）和（III）20/4禁食（禁食/进食20/4小时，n = 8）。对不同禁食干预后的基线心电图参数和心率变异性参数进行分析，结果表明这些干预措施是安全的，在Schellong-1测试期间不会影响心率变异性参数，并且揭示了与禁食干预无关的相当的自主心脏调节（ACM）保留情况。总之，不同的短期禁食干预未显示基于心电图的安全性问题，并且基于心电图和心率变异性评估显示出相当的自主心脏调节。最后，我们的研究主题可能会加强间歇性禁食策略的科学知识，并指出针对健康年轻受试者中发生的代谢疾病和肥胖的潜在临床预防方法。
