胰腺癌患者 cryosurgery 治疗后血清标志物 CA242、CA199、CA125、CEA、TNF-α 和 TSGF 的表达变化。

Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-α and TSGF after cryosurgery in pancreatic cancer patients.

机构信息

Department of Oncology, The GIBH Affiliated Fuda Hospital, Chinese Academy of Sciences, 91 Jude Zhong Road, Chigang, Guangzhou 510305, China.

出版信息

Biotechnol Lett. 2012 Jul;34(7):1235-41. doi: 10.1007/s10529-012-0908-5. Epub 2012 Mar 29.

DOI:10.1007/s10529-012-0908-5

PMID:22456901

Abstract

The presence of serum tumor markers, carbohydrate antigen 242 (CA242), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), tumor-supplied group of factors (TSGF) and tumor necrosis factor-α (TNF-α), is closely associated with invasion and metastasis of many malignancies. The expression of these markers were measured in serum taken from 37 pancreatic cancer patients prior to treatment. Levels of CA242, CA199, CA125, CEA and TNF-α expression correlated with tumor size, clinical stage, tumor differentiation, lymph node and liver metastasis (P < 0.05). One month after cryosurgery, serum levels of these markers were significantly reduced compared with levels prior to cryosurgery (P < 0.05), whereas there was no significant difference was found between serum levels before and after chemotherapy (P > 0.05). Thus, cryosurgery is more effective than chemotherapy for decreasing CA242, CA199, CA125, CEA, TSGF and TNF-α serum levels in these patients.

摘要

血清肿瘤标志物，包括糖链抗原 242（CA242）、糖链抗原 199（CA199）、糖链抗原 125（CA125）、癌胚抗原（CEA）、肿瘤相关物质群（TSGF）和肿瘤坏死因子-α（TNF-α）的存在与许多恶性肿瘤的侵袭和转移密切相关。在治疗前，从 37 名胰腺癌患者的血清中测量了这些标志物的表达水平。CA242、CA199、CA125、CEA 和 TNF-α 的表达水平与肿瘤大小、临床分期、肿瘤分化、淋巴结和肝转移相关（P < 0.05）。冷冻手术后 1 个月，与冷冻手术前相比，这些标志物的血清水平显著降低（P < 0.05），而化疗前后血清水平无显著差异（P > 0.05）。因此，冷冻手术在降低这些患者的 CA242、CA199、CA125、CEA、TSGF 和 TNF-α 血清水平方面比化疗更有效。