Banji D, Banji Otilia J F, Singh Meenu, Annamalai A R
Department of Pharmacology, Nalanda College of Pharmacy, Cherlapally-508 001, India.
Indian J Pharm Sci. 2011 May;73(3):300-2. doi: 10.4103/0250-474X.93522.
The study evaluated the ability of the alcohol extract of Butea frondosa to protect the gastro-duodenal lining from injury inflicted by acetic acid and pyloric ligation in rats. The induced gastric lesions lead to the generation of alkaline phosphatase and pepsin, which serve as important markers of gastric damage. Alcohol extract of Butea frondosa was administered in doses of 10, 100, 300 and 500 mg/kg as a single schedule and for the time dependent studies in a dose of 100 mg/kg for 7, 14, 21 and 28 days, respectively. Our studies reveal a decline in the formation of alkaline phosphatase and pepsin with 300 and 500 mg/kg of the extract and following treatment for 21 and 28 days, respectively. Extract of Butea frondosa produces significant diminution in the formation of gastric markers implying possible gastro-protective action.
该研究评估了紫铆醇提取物对大鼠胃十二指肠黏膜免受乙酸和幽门结扎所致损伤的保护能力。诱导产生的胃损伤会导致碱性磷酸酶和胃蛋白酶的生成，它们是胃损伤的重要标志物。紫铆醇提取物分别以10、100、300和500毫克/千克的剂量单次给药，在时间依赖性研究中，分别以100毫克/千克的剂量给药7、14、21和28天。我们的研究表明，分别用300和500毫克/千克的提取物处理21和28天后，碱性磷酸酶和胃蛋白酶的生成量有所下降。紫铆提取物能显著减少胃标志物的形成，这意味着它可能具有胃保护作用。
