Jalalpure S S, Gadge N B
Department of Pharmacognosy and Phytochemistry, KLE University's College of Pharmacy, JNMC Campus, Nehru Nagar, Belgaum-590 010, Karnataka, India.
Indian J Pharm Sci. 2011 May;73(3):306-11. doi: 10.4103/0250-474X.93525.
The present study was aimed to investigate the diuretic effects of aqueous and crude ethanol extracts of Bombax ceiba L. fruits (family, Bombacaceae) using acute model in rats. A single individual dose of aqueous and ethanol extract of B. ceiba fruit (200 mg/kg and 400 mg/kg, p.o., each), frusemide and hydrochlorothiazide, (25 mg/kg, p.o., each) as reference diuretic drugs, were administered orally to dehydrated rats. Control group rats were fed with normal saline (25 ml/kg, p.o.). All rats were caged in metabolic cages in pairs and their urine output was monitored at 5 and 24 h intervals. Both extracts significantly increased the urine output in higher doses. Although, the onset of this diuretic action was gradual (within 5 h), it lasted throughout the studied period (up to 24 h). Further, the intensity of diuresis induced by aqueous extract (400 mg/kg) in 5 h was almost similar to that of frusemide and hydrochlothiazide. Aqueous extract of B. ceiba fruit also caused marked increase in urinary Na(+) and K(+) levels. However, the routine urinalysis showed non-significant alterations in pH and specific gravity by either dose of crude extracts of B. ceiba fruits. These effects demonstrate possible diuretic actions of B. ceiba fruit extracts and support its folklore use in various urinary ailments. Further studies need to be done to characterize the active phytoconstituents from fruits.
本研究旨在利用大鼠急性模型研究木棉科植物木棉果实的水提取物和粗乙醇提取物的利尿作用。将木棉果实的水提取物和乙醇提取物（各200毫克/千克和400毫克/千克，口服）、速尿和氢氯噻嗪（各25毫克/千克，口服）作为参比利尿药物，口服给予脱水大鼠。对照组大鼠喂食生理盐水（25毫升/千克，口服）。所有大鼠成对关在代谢笼中，每隔5小时和24小时监测其尿量。两种提取物在较高剂量时均显著增加尿量。虽然这种利尿作用起效缓慢（5小时内），但在整个研究期间（长达24小时）持续存在。此外，水提取物（400毫克/千克）在5小时内诱导的利尿强度几乎与速尿和氢氯噻嗪相似。木棉果实的水提取物还使尿钠和钾水平显著升高。然而，常规尿液分析显示，木棉果实粗提取物的任何剂量对pH值和比重均无显著改变。这些作用表明木棉果实提取物可能具有利尿作用，并支持其在各种泌尿系统疾病中的民间应用。需要进一步研究以鉴定果实中的活性植物成分。
