Saleem R, Ahmad M, Hussain S A, Qazi A M, Ahmad S I, Qazi M H, Ali M, Faizi S, Akhtar S, Husnain S N
Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan.
Planta Med. 1999 May;65(4):331-4. doi: 10.1055/s-1999-14060.
Shamimin, a C-flavonol glucoside from Bombax ceiba leaves showed significant potency as a hypotensive agent at the doses of 15 mg/kg, 3 mg/kg, 1 mg/kg and significant hypoglycaemic activity at 500 mg/kg in Sprague-Dawley rats. Further studies revealed that it did not cause any mortality in mice at the dose of 1 g/kg but in rats 500 mg/kg is a lethal dose. Aqueous and methanolic extracts of Bombax ceiba leaves and one of its fractions were also subjected to pharmacological and toxicological screening.
