Shinde Ujwala, Nagarsenker Mangal
Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai-400 098, India.
Indian J Pharm Sci. 2011 May;73(3):311-5. doi: 10.4103/0250-474X.93524.
Present study describes microencapsulation of eugenol using gelatin-sodium alginate complex coacervation. The effects of core to coat ratio and drying method on properties of the eugenol microcapsules were investigated. The eugenol microcapsules were evaluated for surface characteristics, micromeritic properties, oil loading and encapsulation efficiency. Eugenol microcapsules possessed good flow properties, thus improved handling. The scanning electron photomicrographs showed globular surface of microcapsules prepared with core: coat ratio1:1.The treatment with dehydrating agent isopropanol lead to shrinking of microcapsule wall with cracks on it. The percent oil loading and encapsulation efficiency increased with increase in core: coat ratio whereas treatment with dehydrating agent resulted in reduction in loading and percent encapsulation efficiency of eugenol microcapsules.
本研究描述了使用明胶-海藻酸钠复合凝聚法对丁香酚进行微囊化。研究了芯材与包材比例和干燥方法对丁香酚微胶囊性能的影响。对丁香酚微胶囊的表面特性、粉体学性质、载油量和包封率进行了评估。丁香酚微胶囊具有良好的流动性能，从而改善了其操作性。扫描电子显微镜照片显示，芯材与包材比例为1:1制备的微胶囊表面呈球形。用脱水剂异丙醇处理导致微胶囊壁收缩并出现裂缝。载油量百分比和包封率随芯材与包材比例的增加而增加，而用脱水剂处理则导致丁香酚微胶囊的载量和包封率百分比降低。
