Koenig Xaver, Kovar Michael, Boehm Stefan, Sandtner Walter, Hilber Karlheinz
Center for Physiology and Pharmacology, Department of Neurophysiology and - pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria.
Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Waehringerstrasse 13A, 1090 Vienna, Austria.
Addict Biol. 2014 Mar;19(2):237-239. doi: 10.1111/j.1369-1600.2012.00447.x. Epub 2012 Mar 28.
Ibogaine, an alkaloid derived from the African shrub Tabernanthe iboga, has shown promising anti-addictive properties in animals. Anecdotal evidence suggests that ibogaine is also anti-addictive in humans. Thus, it alleviates drug craving and impedes relapse of drug use. Although not licensed as therapeutic drug, and despite evidence that ibogaine may disturb the rhythm of the heart, this alkaloid is currently used as an anti-addiction drug in alternative medicine. Here, we report that therapeutic concentrations of ibogaine reduce currents through human ether-a-go-go-related gene potassium channels. Thereby, we provide a mechanism by which ibogaine may generate life-threatening cardiac arrhythmias.
伊博格碱是一种从非洲灌木伊博格（Tabernanthe iboga）中提取的生物碱，已在动物实验中显示出有前景的抗成瘾特性。轶事证据表明，伊博格碱对人类也有抗成瘾作用。因此，它能减轻药物渴望并阻碍药物使用的复发。尽管未被许可作为治疗药物，且有证据表明伊博格碱可能扰乱心脏节律，但这种生物碱目前在替代医学中被用作抗成瘾药物。在此，我们报告，治疗浓度的伊博格碱会降低通过人类去极化激活的钾离子通道的电流。由此，我们提供了一种机制，通过该机制伊博格碱可能引发危及生命的心律失常。
