Laboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology (IMBICE)-Argentine Research Council (CONICET) and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), Buenos Aires, Argentina.
Biol Psychiatry. 2012 Sep 1;72(5):347-53. doi: 10.1016/j.biopsych.2012.02.016. Epub 2012 Mar 28.
The peptide hormone ghrelin acts in the central nervous system as a potent orexigenic signal. Not only is ghrelin recognized as playing an important role in feeding circuits traditionally thought of as affecting body weight homeostasis, but also an accumulating number of scientific studies have identified ghrelin as being a key regulator of reward-based, hedonic eating behaviors. In the current article, we review ghrelin's orexigenic actions, the evidence linking ghrelin to food reward behavior, potential mechanisms by which ghrelin mediates reward-based eating behavior, and those studies suggesting an obligatory role for ghrelin in the changed eating behaviors induced by stress.
肽激素 ghrelin 在中枢神经系统中作为一种有效的食欲刺激信号发挥作用。ghrelin 不仅被认为在传统上被认为影响体重平衡的进食回路中发挥重要作用，而且越来越多的科学研究已经确定 ghrelin 是奖励性、享乐性进食行为的关键调节因子。在本文中，我们回顾了 ghrelin 的食欲刺激作用、将 ghrelin 与食物奖励行为联系起来的证据、ghrelin 介导奖励性进食行为的潜在机制，以及那些表明 ghrelin 在应激引起的改变的进食行为中具有必需作用的研究。
