Tu Ye, Kuang Xinyi, Zhang Ling, Xu Xin
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Microbiol. 2023 Apr 6;14:1124945. doi: 10.3389/fmicb.2023.1124945. eCollection 2023.
Gut microbiota is of great importance in human health, and its roles in the maintenance of skeletal homeostasis have long been recognized as the "gut-bone axis." Recent evidence has indicated intercorrelations between gut microbiota, endocrine system and bone metabolism. This review article discussed the complex interactions between gut microbiota and bone metabolism-related hormones, including sex steroids, insulin-like growth factors, 5-hydroxytryptamine, parathyroid hormone, glucagon-like peptides, peptide YY, etc. Although the underlying mechanisms still need further investigation, the regulatory effect of gut microbiota on bone health interplaying with endocrine system may provide a new paradigm for the better management of musculoskeletal disorders.
肠道微生物群对人类健康至关重要，其在维持骨骼稳态中的作用长期以来一直被视为“肠-骨轴”。最近的证据表明肠道微生物群、内分泌系统和骨代谢之间存在相互关联。这篇综述文章讨论了肠道微生物群与骨代谢相关激素之间的复杂相互作用，包括性激素、胰岛素样生长因子、5-羟色胺、甲状旁腺激素、胰高血糖素样肽、肽YY等。尽管潜在机制仍需进一步研究，但肠道微生物群与内分泌系统相互作用对骨骼健康的调节作用可能为更好地管理肌肉骨骼疾病提供新的范例。
