Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.
Curr Opin Biotechnol. 2012 Dec;23(6):924-30. doi: 10.1016/j.copbio.2012.03.004. Epub 2012 Mar 28.
Infectious diseases are the leading causes of death worldwide. The development of efficient and low cost prophylactics to prevent pathogenic infection is given high priority in the twenty-first century. Commensal bacteria are largely seen as harmless and can survive symbiotically (in many cases) in niches throughout the human body. Advances in genetic engineering and understanding of pathogenesis have revealed many potential strategies to develop engineered bacteria for prophylaxis purposes: including live vaccines and anti-infective agents. In this review, we discuss recent advances and potentialities of prophylaxis with engineered bacteria.
传染病是全球死亡的主要原因。在 21 世纪，开发高效、低成本的预防措施来预防病原感染被高度重视。共生菌在很大程度上被认为是无害的，并且可以在人体的许多部位共生（在许多情况下）。遗传工程学的进步和对发病机制的理解揭示了许多潜在的策略，可用于开发用于预防目的的工程细菌：包括活疫苗和抗感染剂。在这篇综述中，我们讨论了用工程细菌进行预防的最新进展和潜力。
