Kopczyńska Maria, Franek Andrzej, Błaszczak Edward, Dworak Justyna, Kopczyński Przemysław, Hrycek Antoni
Slaski Uniwersytet Medyczny w Katowicach, Koło Naukowe przy Katedrze i Klinice Chorób Wewnetrznych, Autoimmunologicznych i Metabolicznych.
Pol Merkur Lekarski. 2013 May;34(203):251-4.
Chemokines promote leukocyte traffic into the site of inflammation. It depends on the repertoire of chemokines synthesized locally, and the temporal expression of chemokine receptors on leukocytes among them lymphocytes B and T which play crucial role in the pathogenesis of autoimmune diseases for example in systemic lupus erythematosus (SLE). RANTES (regulated upon activation in normal T cells expressed and secreted) is chemokine influencing T cells and BLC 1 (B-lymphocyte chemoattractant 1) is chemokine which affects B cells. The aim of the study was to evaluate serum concentration of the above mentioned chemokines in treated SLE patients and to analyze the relationships between their concentration in patients group and the control one. Another aim of our study was to assess the relationships between serum levels of these chemokines and the total peripheral blood leukocyte count and between serum levels of these chemokines and absolute peripheral blood counts of the individual forms of these cells in SLE patients.
Serum levels of RANTES and BLC 1 were determined in 48 treated women with SLE and mild-to-moderate disease severity. The results were compared between the total SLE group and the control (29 healthy women). The correlation between chemokines and between their levels and peripheral blood leukocyte count were evaluated. The relationships between the analyzed chemokines were also determined in the control group.
Lower level of RANTES in serum was revealed in patients with SLE compared to the control and the tendency to higher concentration of BLC 1 in serum was observed. No relationships were observed between the levels of these chemokines both in the SLE patients and in the control group. Whereas the negative correlations between BLC 1 and total leukocyte count and BLC 1 and absolute number of neutrophils were found without such correlation between BLC 1 the subgroup of patients with concomitant neutropenia.
We suggest that in treated patients with SLE lowered level of RANTES and tendency to higher level of BLC 1 is observed which have not any connections with the peripheral blood leukocyte counts and individual forms of these cells counts.
趋化因子促进白细胞向炎症部位迁移。这取决于局部合成的趋化因子种类，以及白细胞（包括在自身免疫性疾病发病机制中起关键作用的B淋巴细胞和T淋巴细胞）上趋化因子受体的瞬时表达，例如在系统性红斑狼疮（SLE）中。RANTES（正常T细胞激活时表达和分泌的调节因子）是一种影响T细胞的趋化因子，而BLC 1（B淋巴细胞趋化因子1）是一种影响B细胞的趋化因子。本研究的目的是评估经治疗的SLE患者血清中上述趋化因子的浓度，并分析患者组与对照组中它们浓度之间的关系。我们研究的另一个目的是评估这些趋化因子的血清水平与外周血白细胞总数之间的关系，以及这些趋化因子的血清水平与SLE患者外周血中这些细胞各亚型绝对计数之间的关系。
测定了48例病情为轻至中度且已接受治疗的SLE女性患者血清中RANTES和BLC 1的水平。将SLE患者总组与对照组（29名健康女性）的结果进行比较。评估趋化因子之间及其水平与外周血白细胞计数之间的相关性。还在对照组中确定了所分析趋化因子之间的关系。
与对照组相比，SLE患者血清中RANTES水平较低，且观察到血清中BLC 1浓度有升高趋势。在SLE患者和对照组中，这些趋化因子的水平之间均未观察到相关性。然而，发现BLC 1与白细胞总数以及BLC 1与中性粒细胞绝对数之间存在负相关，而在伴有中性粒细胞减少症的患者亚组中，BLC 1与中性粒细胞绝对数之间不存在这种相关性。
我们认为，在经治疗的SLE患者中，观察到RANTES水平降低和BLC 1水平有升高趋势，这与外周血白细胞计数及这些细胞的各亚型计数无关。
