基于纯化蛋白衍生物的酶联免疫斑点试验在膀胱内卡介苗灌注后牛分枝杆菌卡介苗感染患者中的应用价值。
Added value of use of a purified protein derivative-based enzyme-linked immunosorbent spot assay for patients with Mycobacterium bovis BCG infection after intravesical BCG instillations.
作者信息
Heemstra Karen A, Bossink Ailko W J, Spermon Roan, Bouwman John J M, van der Kieft Robert, Thijsen Steven F T
机构信息
Diakonessenhuis Utrecht, Medical Microbiology and Immunology, Utrecht, The Netherlands.
出版信息
Clin Vaccine Immunol. 2012 Jun;19(6):974-7. doi: 10.1128/CVI.05597-11. Epub 2012 Mar 29.
Abstract
In this case series, we describe four cases in which the use of gamma interferon release assays with purified protein derivative (PPD) as a stimulating antigen was able to demonstrate PPD-specific immune activation. This may help to improve the adequate diagnosis of (systemic) Mycobacterium bovis BCG infections after intravesical BCG instillations for bladder carcinoma.
摘要
在本病例系列中，我们描述了4例病例，其中使用以纯化蛋白衍生物（PPD）作为刺激抗原的γ干扰素释放试验能够证明PPD特异性免疫激活。这可能有助于改善膀胱癌膀胱内卡介苗灌注后（全身性）牛分枝杆菌卡介苗感染的准确诊断。
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