Wilkinson Katalin A, Wilkinson Robert J, Pathan Ansar, Ewer Katie, Prakash Manyu, Klenerman Paul, Maskell Nick, Davies Robert, Pasvol Geoffrey, Lalvani Ajit
Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Clin Infect Dis. 2005 Jan 1;40(1):184-7. doi: 10.1086/426139. Epub 2004 Dec 8.
Presence of early secretory antigenic target-6 (ESAT-6)-specific, interferon- gamma -secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, +/-6-fold), relative to their level in peripheral blood (P=.014), and displayed rapid effector function. Such cells were absent in 8 control patients with nontuberculous pleural disease. The recruitment of ESAT-6-specific T cells to inflamed tuberculous tissue demonstrates their function in vivo and suggests a novel way to diagnose tuberculous pleuritis.
血液中存在早期分泌性抗原靶标6（ESAT-6）特异性、分泌γ干扰素的T细胞可准确标记结核感染。在10例肺结核患者的结核性胸腔积液中，相对于外周血水平，这些细胞平均浓缩了15倍（标准差，±6倍）（P = 0.014），并表现出快速效应功能。8例非结核性胸膜疾病对照患者中不存在此类细胞。ESAT-6特异性T细胞向发炎的结核组织募集证明了它们在体内的功能，并提示了一种诊断结核性胸膜炎的新方法。
