Oliva I B, Cortopassi F, Rochester C L, Rubinowitz A N
Department of Diagnostic Radiology, Yale New Haven Hospital, Yale University School of Medicine, 333 Cedar St, NP 2 2003, New Haven, CT 06520-8042, USA.
Monaldi Arch Chest Dis. 2011 Dec;75(4):220-34. doi: 10.4081/monaldi.2011.210.
Chronic obstructive pulmonary disease (that includes emphysema) results in significant morbidity and mortality worldwide. Idiopathic pulmonary fibrosis (IPF) is also a chronic and progressive parenchymal lung disease with an average survival of less than 5 years after diagnosis. Combined pulmonary fibrosis and emphysema (CPFE) is an important but still underdiagnosed syndrome. Its diagnosis is based on the radiological findings at computed tomography which consists of emphysema of the upper lung zones and fibrosis of the lower lung zones. Since this syndrome has a very bad prognosis, even worse than isolated finding of emphysema or fibrosis alone, early recognition and rapid treatment are important. In this article we will review and elucidate the radiologic appearance of this syndrome and highlight its clinical importance.
慢性阻塞性肺疾病（包括肺气肿）在全球范围内导致了显著的发病率和死亡率。特发性肺纤维化（IPF）也是一种慢性进行性实质性肺病，诊断后平均生存期不到5年。合并性肺纤维化和肺气肿（CPFE）是一种重要但仍未得到充分诊断的综合征。其诊断基于计算机断层扫描的影像学表现，即上肺区肺气肿和下肺区纤维化。由于该综合征预后极差，甚至比单纯的肺气肿或纤维化更差，因此早期识别和快速治疗至关重要。在本文中，我们将回顾并阐明该综合征的影像学表现，并强调其临床重要性。
