Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, 600 Moye Blvd, Greenville, NC 28590, USA.
Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):21-5. doi: 10.1016/j.plefa.2012.03.004. Epub 2012 Mar 29.
Bioactive n-3 polyunsaturated fatty acids (PUFA), abundant in fish oil, have potential for treating symptoms associated with inflammatory and metabolic disorders; therefore, it is essential to determine their fundamental molecular mechanisms. Recently, several labs have demonstrated the n-3 PUFA docosahexaenoic acid (DHA) exerts anti-inflammatory effects by targeting the molecular organization of plasma membrane microdomains. Here we briefly review the evidence that DHA reorganizes the spatial distribution of microdomains in several model systems. We then emphasize how models on DHA and plasma membrane microdomains can be applied to mitochondrial membranes. We discuss the role of DHA acyl chains in regulating mitochondrial lipid-protein clustering, and how these changes alter several aspects of mitochondrial function. In particular, we summarize effects of DHA on mitochondrial respiration, electron leak, permeability transition, and mitochondrial calcium handling. Finally, we conclude by postulating future experiments that will augment our understanding of DHA-dependent membrane organization in health and disease.
富含于鱼油中的生物活性 n-3 多不饱和脂肪酸（PUFA）具有治疗与炎症和代谢紊乱相关症状的潜力；因此，确定其基本分子机制至关重要。最近，几个实验室已经证明 n-3 PUFA 二十二碳六烯酸（DHA）通过靶向质膜微域的分子组织发挥抗炎作用。在这里，我们简要回顾了 DHA 重组几个模型系统中微域空间分布的证据。然后，我们强调了 DHA 和质膜微域模型如何应用于线粒体膜。我们讨论了 DHA 酰基链在调节线粒体脂 - 蛋白聚集中的作用，以及这些变化如何改变线粒体功能的几个方面。特别是，我们总结了 DHA 对线粒体呼吸、电子泄漏、通透性转换和线粒体钙处理的影响。最后，我们推测未来的实验将增强我们对 DHA 依赖性膜组织在健康和疾病中的理解。
