Nørredam K
Acta Pathol Microbiol Scand A. 1979 Jul;87A(4):227-36.
Among 7763 autopsies performed in Greater Copenhagen in 1973, there were 309 cases of cirrhosis of the liver and 52 cases of primary carcinoma of the liver (PCL). Of the latter, 45 were hepatocellular carcinoma (HCC), 4 combined HCC and cholangiocarcinoma (CCC) and 3 CCC. HCC was found in 7.8 per cent of the cirrhotic livers and was in 57.1 per cent accompagnied by cirrhosis. The criteria of WHO, Peters (modified) and Anthony were used for classification. The degree of differentiation of the tumours was estimated using the criteria of WHO and Edmondson. The apparently small number of CCC may be due to the fact that this tumour is often overdiagnosed at the expense of HCC. The incidence of combined tumours is probably higher than generally assumed. The reticulin stain was found very valuable in HCC, both for descriptive and diagnostic purposes. In contrast to the situation in sub-Saharan Africa where hepatitis B virus is incriminated as the most important etiologic factor of HCC, it was found in the present study that alcoholism was a very essential cause of cirrhosis and thereby of HCC.
1973年在大哥本哈根地区进行的7763例尸检中，有309例肝硬化病例和52例原发性肝癌（PCL）病例。在后者中，45例为肝细胞癌（HCC），4例为HCC合并胆管癌（CCC），3例为CCC。HCC在7.8%的肝硬化肝脏中被发现，并且57.1%伴有肝硬化。采用世界卫生组织（WHO）、彼得斯（修订版）和安东尼的标准进行分类。使用WHO和埃德蒙森的标准评估肿瘤的分化程度。CCC数量明显较少可能是因为这种肿瘤常常被过度诊断而牺牲了HCC。联合肿瘤的发病率可能比一般认为的要高。网状纤维染色在HCC中被发现非常有价值，无论是用于描述还是诊断目的。与撒哈拉以南非洲地区的情况相反，在那里乙型肝炎病毒被认为是HCC最重要的病因，而在本研究中发现酗酒是肝硬化进而也是HCC的一个非常重要的原因。
