University Center for Geriatric Medicine, University of Groningen, Univerity Medical Center Groningen, Groningen, the Netherlands.
Neurobiol Aging. 2012 Aug;33(8):1851.e7-16. doi: 10.1016/j.neurobiolaging.2012.02.022. Epub 2012 Mar 29.
Common polymorphisms of the Cholestryl Ester Transfer Protein (CETP) gene may predict lower risk of cognitive decline. We investigated the association of cognitive function with CETP genotype in a population-based cohort of 4135 persons aged 35-82 years. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points) and CETP I405V and Taq1B genotypes were determined by polymerase chain reaction. RFFT score was not associated with I405V genotype in persons aged 35-64 years. Remarkably, beyond age 65, homozygous valine carriers had higher RFFT scores than heterozygous carriers and noncarriers: RFFT (SD), 52 (21), 49 (18), and 47 (17) points, respectively (p = 0.005). There also was a statistically significant interaction between I405V genotype and age. Beyond age 65, the difference between homozygous valine carriers and noncarriers increased by 0.11 point per year (p = 0.005). RFFT score was not associated with Taq1B genotype. In conclusion, CETP I405V valine homozygosity was associated with better cognitive function in persons aged 65 years or older.
载脂蛋白 E 转移蛋白（CETP）基因的常见多态性可能预示着认知能力下降的风险较低。我们在一个基于人群的队列中研究了认知功能与 CETP 基因型的关系，该队列由 4135 名年龄在 35-82 岁的个体组成。认知功能采用 Ruff 图形流畅性测试（RFFT；最差得分为 0 分，最好得分为 175 分）进行测量，CETP I405V 和 Taq1B 基因型通过聚合酶链反应确定。在年龄在 35-64 岁的人群中，RFFT 评分与 I405V 基因型无关。值得注意的是，65 岁以上，纯合子缬氨酸携带者的 RFFT 评分高于杂合子携带者和非携带者：RFFT（SD）分别为 52（21）、49（18）和 47（17）分（p = 0.005）。I405V 基因型和年龄之间也存在显著的交互作用。65 岁以上，纯合子缬氨酸携带者和非携带者之间的差异每年增加 0.11 分（p = 0.005）。RFFT 评分与 Taq1B 基因型无关。总之，CETP I405V 缬氨酸纯合子与 65 岁或以上人群的认知功能较好相关。
