Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute/NIH, Two Rockledge Center, 6701 Rockledge Drive, Bethesda, MD 20892-7956, USA.
J Am Coll Cardiol. 2012 Apr 3;59(14):1263-9. doi: 10.1016/j.jacc.2011.11.050.
The National Heart, Lung, and Blood Institute (NHLBI) convened a Working Group (WG) on August 5 to 6, 2010 in Bethesda, Maryland to discuss future directions of research in heart transplantation (HT). The WG was composed of researchers with expertise in the basic science, clinical science, and epidemiological aspects of advanced heart failure and HT. These experts were asked to identify the highest priority research gaps in the field and make recommendations for future research strategies. The WG was also asked to include approaches that capitalize on current scientific opportunities and focus on areas that required unique NHLBI leadership. Finally, the WG was charged with developing recommendations that would have short- and long-term impact on the field of HT. The WG participants reviewed key areas in HT and identified the most urgent knowledge gaps. These gaps were then organized into the following 4 specific research directions: 1) enhanced phenotypic characterization of the pre-transplant population; 2) donor-recipient optimization strategies; 3) individualized immunosuppression therapy; and, 4) investigations of immune and non-immune factors affecting late cardiac allograft outcomes. Finally, because the HT population is relatively small compared with other patient groups, the WG strongly urged concerted efforts to enroll every transplant recipient into a clinical study and to increase collaborative networks to optimize research in this field.
美国国立心肺血液研究所（NHLBI）于 2010 年 8 月 5 日至 6 日在马里兰州贝塞斯达召集了一个工作组（WG），讨论心脏移植（HT）领域的未来研究方向。该工作组由在心力衰竭和 HT 的基础科学、临床科学和流行病学方面具有专业知识的研究人员组成。这些专家被要求确定该领域最高优先级的研究差距，并为未来的研究策略提出建议。该工作组还被要求纳入利用当前科学机会的方法，并专注于需要 NHLBI 独特领导的领域。最后，工作组负责制定对 HT 领域具有短期和长期影响的建议。工作组的参与者审查了 HT 的关键领域，并确定了最紧迫的知识差距。然后，这些差距被组织成以下 4 个具体的研究方向：1）增强移植前人群的表型特征描述；2）供体-受者优化策略；3）个体化免疫抑制治疗；4）研究影响晚期心脏移植物结局的免疫和非免疫因素。最后，由于与其他患者群体相比，HT 人群相对较小，工作组强烈敦促齐心协力，将每位移植受者纳入临床研究，并增加合作网络，以优化该领域的研究。
