UniProtKB/Swiss-Prot 的 Tox-Prot 程序：整合毒液蛋白数据的中心枢纽。
The UniProtKB/Swiss-Prot Tox-Prot program: A central hub of integrated venom protein data.
机构信息
Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel-Servet, 1211 Genève 4, Switzerland.
出版信息
Toxicon. 2012 Sep 15;60(4):551-7. doi: 10.1016/j.toxicon.2012.03.010. Epub 2012 Mar 23.
Abstract
Animal toxins are of interest to a wide range of scientists, due to their numerous applications in pharmacology, neurology, hematology, medicine, and drug research. This, and to a lesser extent the development of new performing tools in transcriptomics and proteomics, has led to an increase in toxin discovery. In this context, providing publicly available data on animal toxins has become essential. The UniProtKB/Swiss-Prot Tox-Prot program (http://www.uniprot.org/program/Toxins) plays a crucial role by providing such an access to venom protein sequences and functions from all venomous species. This program has up to now curated more than 5000 venom proteins to the high-quality standards of UniProtKB/Swiss-Prot (release 2012_02). Proteins targeted by these toxins are also available in the knowledgebase. This paper describes in details the type of information provided by UniProtKB/Swiss-Prot for toxins, as well as the structured format of the knowledgebase.
摘要
动物毒素引起了广泛科学家的关注，因为它们在药理学、神经学、血液学、医学和药物研究中有众多应用。这一点，以及在转录组学和蛋白质组学方面开发新的表现工具的作用，导致了毒素发现的增加。在这种情况下，提供关于动物毒素的公开可用数据变得至关重要。UniProtKB/Swiss-Prot Tox-Prot 计划（http://www.uniprot.org/program/Toxins）通过提供这种访问权限，从所有有毒物种中获取毒液蛋白序列和功能，发挥了至关重要的作用。该计划迄今已按照 UniProtKB/Swiss-Prot（2012_02 版）的高质量标准整理了 5000 多种毒液蛋白。这些毒素靶向的蛋白质也可在知识库中获得。本文详细描述了 UniProtKB/Swiss-Prot 为毒素提供的信息类型，以及知识库的结构化格式。
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