Department of Otolaryngology, Teikyo University School of Medicine Mizonokuchi Hospital, 3-8-3 Mizonokuchi, Kawasaki 213-8507, Japan.
Neurosci Lett. 2012 May 2;515(2):103-6. doi: 10.1016/j.neulet.2012.02.084. Epub 2012 Mar 23.
The otolith-ocular reflex in patients with episodic lateral tilt sensation without any other vestibular symptoms was assessed using ocular vestibular evoked myogenic potentials (oVEMP). Ten patients (6 men and 4 women, mean age=53.5) were enrolled. All patients had episodic lateral tilt sensation. Patients with a medical history of rotatory vertigo, loss of consciousness, head trauma, or symptoms or signs of central nervous dysfunction or proprioceptive dysfunction and those who had been definitely diagnosed with a disease that causes disequilibrium were excluded. All of the 10 patients had oVEMP tests and cervical VEMP (cVEMP) tests and underwent caloric tests. Eight of the 10 patients showed unilateral absence of oVEMP, one displayed a bilateral absence, and one displayed normal oVEMP. Concerning cVEMP, 4 patients showed a unilateral absence of cVEMP, one displayed unilaterally decreased responses and 5 displayed normal cVEMP. All patients showed normal bilateral caloric responses. The present study showed that patients with episodic lateral tilt sensation displayed abnormal otolith-ocular reflexes, as shown by their oVEMP, suggesting that these patients were suffering from utricular dysfunction.
采用眼震电图诱发肌源性电位(oVEMP)评估了无其他前庭症状的阵发性侧倾感患者的耳石-眼反射。共纳入 10 名患者(6 名男性和 4 名女性，平均年龄=53.5)。所有患者均有阵发性侧倾感。排除既往有旋转性眩晕、意识丧失、头部外伤史，或有中枢神经系统功能障碍或本体感觉功能障碍症状或体征，以及已明确诊断为引起平衡障碍疾病的患者。所有 10 名患者均进行了 oVEMP 测试和颈性前庭诱发肌源性电位(cVEMP)测试，并进行了冷热测试。10 名患者中有 8 名表现为单侧 oVEMP 缺失，1 名表现为双侧 oVEMP 缺失，1 名表现为正常 oVEMP。关于 cVEMP，4 名患者表现为单侧 cVEMP 缺失，1 名患者表现为单侧反应减弱，5 名患者表现为正常 cVEMP。所有患者双侧冷热反应均正常。本研究表明，阵发性侧倾感患者的耳石-眼反射异常，oVEMP 异常，提示这些患者存在前庭器功能障碍。
