Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Dev Biol. 2012 Jun 1;366(1):55-63. doi: 10.1016/j.ydbio.2012.02.038. Epub 2012 Mar 10.
Elucidating the mechanisms by which multipotent cells differentiate into distinct lineages is a common theme underlying developmental biology investigations. Progress has been made in understanding some of the essential factors and pathways involved in the specification of different lineages from the neural crest. These include gene regulatory networks involving transcription factor hierarchies and input from signaling pathways mediated from environmental cues. In this review, we examine the mechanisms for two lineages that are derived from the neural crest, peripheral sensory neurons and melanocytes. Insights into the specification of these cell types may reveal common themes in the specification processes that occur throughout development.
阐明多能细胞分化为不同谱系的机制是发育生物学研究的一个共同主题。人们在理解神经嵴中不同谱系特化所涉及的一些基本因子和途径方面已经取得了进展。这些包括涉及转录因子层次结构的基因调控网络，以及来自环境线索的信号通路的输入。在这篇综述中，我们研究了源自神经嵴的两个谱系的机制，即周围感觉神经元和黑色素细胞。对这些细胞类型的特化的深入了解可能揭示出发生在整个发育过程中的特化过程中的共同主题。
