Department of Gastroenterology, Changzhou No 2 Hospital, Affiliated with Nanjing Medical University, Changzhou City, Jiangsu Province, China.
Inflamm Bowel Dis. 2013 Jan;19(1):54-60. doi: 10.1002/ibd.22966.
Several polymorphisms have been identified in the vitamin D receptor (VDR) gene, while their roles in the incidence of ulcerative colitis (UC) and Crohn's disease (CD) are conflicting. This meta-analysis was designed to clarify the impact of these polymorphisms on UC and CD risk.
The PubMed, Embase, and Cochrane electronic databases were searched from February 1995 to August 2011 for studies on the four VDR polymorphisms: TaqI, BsmI, FokI, and ApaI. Data were extracted and pooled odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.
Nine studies were included. In Asians, the ff genotype of FokI was associated with increased UC risk (OR = 1.65; 95% CI, 1.11- 2.45). The "a" allele carrier status of ApaI appeared to be a protective factor for CD (OR = 0.81; 95% CI, 0.67-0.97). The tt genotype increased the risk of CD in Europeans (OR = 1.23; 95% CI, 1.02-1.49). Moreover, the tt genotype of TaqI in males had a moderate elevated risk of UC (OR = 1.56; 95% CI, 1.02-2.39) and CD (OR = 1.84; 95% CI, 1.19-2.83).
The meta-analysis reveals a significant increase in CD risk for Europeans carrying TaqI tt genotype and a significant decrease in CD risk for all carriers of the Apal "a" allele. For Asians, the VDR FokI polymorphism appears to confer susceptibility to UC. For males, the TaqI tt genotype is associated with susceptibilities to both UC and CD. Our study explored the genetic risk prediction in UC and CD, and may provide valuable insights into IBD therapy.
维生素 D 受体（VDR）基因中的几种多态性已被鉴定出来，但其在溃疡性结肠炎（UC）和克罗恩病（CD）发病中的作用存在争议。本荟萃分析旨在阐明这些多态性对 UC 和 CD 风险的影响。
从 1995 年 2 月至 2011 年 8 月，我们检索了 PubMed、Embase 和 Cochrane 电子数据库，以获取关于 VDR 四种多态性（TaqI、BsmI、FokI 和 ApaI）的研究。提取数据并计算比值比（OR）和 95%置信区间（95%CI）。
纳入了 9 项研究。在亚洲人群中，FokI 的 ff 基因型与 UC 风险增加相关（OR=1.65；95%CI，1.11-2.45）。ApaI 的“a”等位基因携带者似乎是 CD 的保护因素（OR=0.81；95%CI，0.67-0.97）。欧洲人群中 TaqI 的 tt 基因型增加了 CD 的风险（OR=1.23；95%CI，1.02-1.49）。此外，男性 TaqI 的 tt 基因型 UC（OR=1.56；95%CI，1.02-2.39）和 CD（OR=1.84；95%CI，1.19-2.83）的风险中度升高。
荟萃分析显示，携带 TaqI tt 基因型的欧洲人 CD 风险显著增加，所有 Apal“a”等位基因携带者的 CD 风险显著降低。对于亚洲人群，VDR FokI 多态性似乎与 UC 易感性有关。对于男性，TaqI 的 tt 基因型与 UC 和 CD 的易感性有关。本研究探讨了 UC 和 CD 的遗传风险预测，可能为 IBD 治疗提供有价值的见解。
