Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, 400, Taiwan.
Division of Gastroenterology, Changhua Christian Hospital, Changhua, 500, Taiwan.
Sci Rep. 2024 Jun 18;14(1):14091. doi: 10.1038/s41598-024-64930-8.
Vitamin D deficiency is common in patients with inflammatory bowel disease (IBD). In this study, we aimed to evaluate the prevalence and risk factors of vitamin D deficiency in a Taiwanese IBD cohort. Vitamin D levels were checked in adult patients with IBD who were treated at Changhua Christian Hospital, a medical center in central Taiwan, from January 2017 to December 2023. The risk factors for vitamin D deficiency were evaluated. 106 adult IBD patients were included, including 20 patients with Crohn's disease and 86 with ulcerative colitis. The median age at diagnosis was 39.2 years. The mean vitamin D level was 22.2 ± 8 ng/mL. Forty-five patients (42.5%) had vitamin D deficiency (vitamin D level < 20 ng/mL). Comparing patients with normal vitamin D levels and those with vitamin D deficiency after multivariate adjustment, female sex and early age at diagnosis were identified as statistically significant risk factors. We found a prevalence of 42.5% of vitamin D deficiency in the Taiwanese IBD population. Understanding this issue is essential for teaching patients and doctors about vitamin D deficiency screening and improving patient outcomes.
维生素 D 缺乏症在炎症性肠病（IBD）患者中很常见。本研究旨在评估台湾 IBD 患者维生素 D 缺乏的患病率和危险因素。对 2017 年 1 月至 2023 年 12 月在台湾中部医疗中心彰化基督教医院接受治疗的成年 IBD 患者进行维生素 D 水平检查。评估了维生素 D 缺乏的危险因素。共纳入 106 例成年 IBD 患者，包括 20 例克罗恩病患者和 86 例溃疡性结肠炎患者。诊断时的中位年龄为 39.2 岁。平均维生素 D 水平为 22.2±8ng/mL。45 例（42.5%）存在维生素 D 缺乏症（维生素 D 水平<20ng/mL）。经过多变量调整后，与维生素 D 水平正常的患者相比，维生素 D 缺乏的患者中女性和诊断时年龄较小被确定为具有统计学意义的危险因素。我们发现台湾 IBD 人群中维生素 D 缺乏症的患病率为 42.5%。了解这一问题对于向患者和医生教授维生素 D 缺乏症筛查以及改善患者预后至关重要。
