Lee Young Ho, Woo Jin Hyun, Choi Seong Jae, Ji Jong Dae, Song Gwan Gyu
Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, 126-1 ga, Anam-dong, Seongbuk-gu, Seoul 136-705, Republic of Korea.
Joint Bone Spine. 2009 Mar;76(2):156-61. doi: 10.1016/j.jbspin.2008.06.011. Epub 2008 Dec 13.
Genetic factors may play a role in the development of osteoarthritis (OA), and vitamin D receptor (VDR) polymorphisms have been associated with several common diseases including OA by some studies. The aim of this study was to explore whether the VDR polymorphisms confer susceptibility to OA.
We conducted meta-analyses on the associations between the VDR TaqI, BsmI, ApaI polymorphisms and OA using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) contrast of homozygotes, using fixed and random effects models.
A total of 10 relevant studies on VDR polymorphisms and OA were included in this meta-analysis, which involved in total 1591 OA patients and 1781 controls. Nine studies were performed on VDR TaqI polymorphisms, 6 on VDR BsmI polymorphisms, 5 on VDR ApaI polymorphisms. Accordingly, to our meta-analysis of VDR TaqI polymorphisms, no association was found between OA and the VDR TaqI T allele among in all study subjects (OR=0.841, 95% CI=0.663-1.067, p=0.155). Stratification by ethnicity yielded no association between the VDR TaqI T allele and OA in Europeans or Asians. Moreover, no association was found between OA and the VDR TaqI polymorphisms by the meta-analyses of recessive and dominant models, and contrast of homozygotes. No association was found between OA and the VDR polymorphisms with respect to the BsmI and ApaI polymorphisms by meta-analyses.
No association was found between the VDR TaqI, BsmI, or ApaI polymorphisms and OA susceptibility by this meta-analysis, which included 3372 subjects.
遗传因素可能在骨关节炎（OA）的发病中起作用，一些研究表明维生素D受体（VDR）基因多态性与包括OA在内的多种常见疾病有关。本研究旨在探讨VDR基因多态性是否会使个体易患OA。
我们使用固定效应模型和随机效应模型，对VDR TaqI、BsmI、ApaI基因多态性与OA之间的关联进行了荟萃分析，分析方法包括：（1）等位基因对比；（2）隐性模型；（3）显性模型；（4）纯合子对比。
本荟萃分析共纳入10项关于VDR基因多态性与OA的相关研究，共计1591例OA患者和1781例对照。其中9项研究涉及VDR TaqI基因多态性，6项涉及VDR BsmI基因多态性，5项涉及VDR ApaI基因多态性。因此，在我们对VDR TaqI基因多态性的荟萃分析中，在所有研究对象中未发现OA与VDR TaqI T等位基因之间存在关联（OR = 0.841，95%CI = 0.663 - 1.067，p = 0.155）。按种族分层后，在欧洲人或亚洲人中，VDR TaqI T等位基因与OA之间也未发现关联。此外，通过隐性和显性模型以及纯合子对比的荟萃分析，未发现OA与VDR TaqI基因多态性之间存在关联。通过荟萃分析，未发现OA与VDR基因多态性在BsmI和ApaI基因多态性方面存在关联。
本荟萃分析纳入3372名受试者，未发现VDR TaqI、BsmI或ApaI基因多态性与OA易感性之间存在关联。
