质子泵抑制剂在喉咽反流管理中的临床表现及作用
Clinical manifestations and role of proton pump inhibitors in the management of laryngopharyngeal reflux.
作者信息
Patigaroo Suhail Amin, Hashmi S F, Hasan Syed Abrar, Ajmal M R, Mehfooz Nazia
出版信息
Indian J Otolaryngol Head Neck Surg. 2011 Apr;63(2):182-9. doi: 10.1007/s12070-011-0253-3. Epub 2011 Apr 30.
Abstract
Laryngopharyngeal reflux (LPR) refers to the backflow of stomach contents into the throat that is into the hypopharynx. LPR is different from classical Gastroesophageal reflux disease (GERD) in many ways. Proton pump inhibitors have become the treatment of choice even though conflicting results exists in their response. Treatment requires acid suppression to be as complete as possible and treatment failure is not uncommon. In this article we present here our prospective study of 50 patients diagnosed as a case of LPR on the basis of reflux finding score and reflux symptom index. We tried to evaluate the role of PPI in LPR management by observing the effect of PPI on reflux finding score (RFS) and reflux symptom index (RFI) during the follow up period of 16 weeks.
摘要
喉咽反流（LPR）是指胃内容物反流至咽喉，即下咽。LPR在许多方面与经典的胃食管反流病（GERD）不同。尽管质子泵抑制剂的反应存在矛盾的结果，但已成为治疗的首选。治疗需要尽可能完全地抑制胃酸，治疗失败并不罕见。在本文中，我们展示了对50例根据反流发现评分和反流症状指数诊断为LPR病例的前瞻性研究。我们试图通过观察质子泵抑制剂在16周随访期内对反流发现评分（RFS）和反流症状指数（RFI）的影响，来评估其在LPR管理中的作用。
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