Loose J H, el-Naggar A K, Ro J Y, Huang W L, McMurtrey M J, Ayala A G
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
J Thorac Cardiovasc Surg. 1990 Dec;100(6):867-73.
Two cases of primary osteosarcoma of the lung are presented. In one case, the radiologic, clinical, and cytologic findings led to a preoperative diagnosis of undifferentiated carcinoma of the lung. In the second case, a lung nodule was discovered during postchemotherapy follow-up in a patient with lymphoma. Fine needle aspiration in the second case showed lymphoma, and further chemotherapy was instituted; however, persistent growth of the nodule prompted a resection. Microscopic examination of the resected tumors in both cases revealed histologic features of high-grade osteosarcoma. Flow cytometric analyses of the primary tumors showed abnormal hyperdiploid deoxyribonucleic acid populations in accordance with those seen in high-grade malignant neoplasms. Immunohistochemical studies supported a mesenchymal origin for these tumors. These tumors shared clinical features with other reported cases of primary osteosarcoma of the lung such as large size at diagnosis, occurrence in older individuals, and aggressive behavior.
本文报告了两例原发性肺骨肉瘤病例。其中一例，放射学、临床及细胞学检查结果术前诊断为肺未分化癌。第二例，在一名淋巴瘤患者化疗后随访期间发现肺部结节。第二例经细针穿刺显示为淋巴瘤，遂进一步进行化疗；然而，结节持续生长促使进行了切除术。两例切除肿瘤的显微镜检查均显示为高级别骨肉瘤的组织学特征。对原发性肿瘤的流式细胞术分析显示，存在异常超二倍体脱氧核糖核酸群体，与高级别恶性肿瘤所见相符。免疫组织化学研究支持这些肿瘤起源于间充质。这些肿瘤与其他已报道的原发性肺骨肉瘤病例具有共同的临床特征，如诊断时体积较大、发生于老年个体以及侵袭性生长行为。
