Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Oncol Rep. 2012 Jun;27(6):2073-9. doi: 10.3892/or.2012.1749. Epub 2012 Mar 27.
Metadherin (MTDH), which is an HIV-1 or TNF-α-inducible transcript, has a crucial role in several types of cancer by regulating multiple cellular signaling processes. However, to date, the role of MTDH in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is still unclear. In the present study, we detected MTDH expression in normal liver, chronic hepatitis B and HBV-related HCC tissues. The data showed that MTDH expression levels were elevated in the hepatitis B tissues and especially in the HBV-related HCC tissues compared to normal liver tissues. There was a trend for gradually increased MTDH expression from normal liver tissue to hepatitis B and HBV-related HCC tissues. Furthermore, a statistical analysis revealed that MTDH expression significantly correlated with the American Joint Committee on Cancer (AJCC, 7th edition) stage (P=0.020), T classification (P=0.007), N classification (P=0.044), vascular invasion (P=0.006) and histological differentiation (P=0.020) in the HBV-related HCC patients. In addition, patients with high MTDH levels had shorter survival times compared to those with low MTDH expression (P=0.001). Taken together, these results suggest that MTDH could be a potential prognostic marker for overall survival and tumor progression and a chemotherapeutic target in HBV-related HCC patients.
MTDH（metadherin）是一种 HIV-1 或 TNF-α诱导的转录物，通过调节多种细胞信号转导过程，在多种类型的癌症中发挥关键作用。然而，迄今为止，MTDH 在乙型肝炎病毒（HBV）相关肝细胞癌（HCC）中的作用尚不清楚。在本研究中，我们检测了正常肝、慢性乙型肝炎和 HBV 相关 HCC 组织中的 MTDH 表达。数据显示，HBV 组织中 MTDH 表达水平升高，尤其是在 HBV 相关 HCC 组织中。MTDH 表达水平从正常肝组织到乙型肝炎和 HBV 相关 HCC 组织逐渐升高。此外，统计分析显示，MTDH 表达与美国癌症联合委员会（AJCC，第 7 版）分期（P=0.020）、T 分类（P=0.007）、N 分类（P=0.044）、血管侵犯（P=0.006）和组织学分化（P=0.020）显著相关在 HBV 相关 HCC 患者中。此外，MTDH 水平较高的患者的总生存期短于 MTDH 表达水平较低的患者（P=0.001）。总之，这些结果表明 MTDH 可能是 HBV 相关 HCC 患者总生存期和肿瘤进展的潜在预后标志物，也是化疗的靶点。
