Wilander E, Grimelius L, Lundqvist G, Skoog V
Am J Pathol. 1979 Aug;96(2):519-30.
The morphology and histochemistry of gastroduodenal endocrine tumors from 16 patients were studied. All patients underwent operation, in most cases with a preoperative diagnosis of nonendocrine tumor, ulcer, o polyp(s). The argentaffin reaction was positive in three tumors, and the Hellerström--Hellman argyrophil reaction was positive in four tumors. All tumors reacted positively to the Grimelius argyrophil stain, and 13 were positive with the Sevier--Munger argyrophil stain. Gastrin immunoreactivity was found in eight tumors, and substance-P immunoreactivity in seven tumors. No enteroglucagon, adrenal cortex hormone, or pancreatic polypeptide was observed in any of the tumors. Three patients with Sevier--Munger-positive gastric tumors had concurrent pernicious anemia, and 2 patients with gastrin-immunoreactive tumors had acute or chronic gastroduodenal ulceration. The results indicate that the gastroduodenal endocrine tumor as a rule gives no endocrine symptoms and that the tumor type is an unexpected finding at operation. The tumors may contain gastrin, substance P, somatostatin, and serotonin and tend to be multihormonal.
对16例胃十二指肠内分泌肿瘤的形态学和组织化学进行了研究。所有患者均接受了手术，大多数病例术前诊断为非内分泌肿瘤、溃疡或息肉。嗜银反应在3例肿瘤中呈阳性，赫勒斯特伦-赫尔曼嗜银反应在4例肿瘤中呈阳性。所有肿瘤对格里梅利乌斯嗜银染色均呈阳性反应，13例对塞维耶-芒格嗜银染色呈阳性。在8例肿瘤中发现胃泌素免疫反应性，7例肿瘤中发现P物质免疫反应性。在任何肿瘤中均未观察到肠高血糖素、肾上腺皮质激素或胰多肽。3例塞维耶-芒格染色阳性的胃肿瘤患者并发恶性贫血，2例胃泌素免疫反应性肿瘤患者有急性或慢性胃十二指肠溃疡。结果表明，胃十二指肠内分泌肿瘤通常不产生内分泌症状，肿瘤类型是手术中意外发现的。这些肿瘤可能含有胃泌素、P物质、生长抑素和5-羟色胺，并且往往是多激素性的。
