Das Premlata, Das Balbhadra Prasad, Rauniar Gajendra Prasad, Roy Ranendra Kumar, Sharma Sanjib Kumar
Department of Clinical Pharmacology and Therapeutics, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
Indian J Physiol Pharmacol. 2011 Jul-Sep;55(3):272-80.
An observational follow up study conducted for one year at a tertiary care centre in 154 newly diagnosed diabetes mellitus patients is presented. The aims of the study were to determine the demographics, prescribing patterns, drug cost and analyze effectiveness of different therapies. Effectiveness of therapies were analyzed in patients achieving glycemic control by Wilcoxon signed- rank test. Majority of patients (n = 114) fell into the middle age strata of 35-64 years and 97% were type 2 diabetics. A total of 282 prescriptions were screened that included antidiabetics and other drug categories. Mean number of drugs per prescription sheet was 1.83 +/- 1.31. Oral hypoglycemic agents were advised to 64% of the patients. The prescribing frequency of biguanides (24.5%) was more than sulphonylureas (19.9%). Only 67 patients followed up for 3 months +/- 15 days, of which 46 achieved glycemic control. The biguanides only group (p = 0.002) and combination therapy of biguanides and sulphonylureas group (p = 0.005) were the highly effective therapies, as their p values of fasting blood glucose levels on follow up were the lowest. Nearly 90% of patients on combination therapy achieved glycemic control. In conclusion, this study reflects the therapeutic approach followed in diabetes mellitus as optimal. Future research on a larger patient population is warranted to evaluate existing patterns of therapy for sound practice and quality of care.
本文介绍了在一家三级医疗中心对154名新诊断的糖尿病患者进行的为期一年的观察性随访研究。该研究的目的是确定人口统计学特征、处方模式、药物成本，并分析不同治疗方法的有效性。通过Wilcoxon符号秩检验分析了血糖得到控制的患者的治疗效果。大多数患者（n = 114）处于35 - 64岁的中年年龄段，97%为2型糖尿病患者。共筛选了282张处方，包括抗糖尿病药物和其他药物类别。每张处方的平均药物数量为1.83 +/- 1.31。64%的患者被建议使用口服降糖药。双胍类药物的处方频率（24.5%）高于磺脲类药物（19.9%）。仅67名患者随访了3个月 +/- 15天，其中46名患者血糖得到控制。仅使用双胍类药物的组（p = 0.002）和双胍类药物与磺脲类药物联合治疗组（p = 0.005）是高效治疗方法，因为它们随访时空腹血糖水平的p值最低。接受联合治疗的患者中近90%血糖得到控制。总之，本研究反映出糖尿病的治疗方法是最佳的。有必要对更多患者进行未来研究，以评估现有治疗模式，确保良好的医疗实践和医疗质量。
